NEW YORK PSYCHOANALYTIC SOCIETY & INSTITUTE:
Arnold Pfeffer Center for Neuropsychoanalysis
Marianne and Nicholas Young Auditorium
247 East 82nd St., between 2nd & 3rd, NY, NY 10028
212-879-6900
www.psychoanalysis.org
www.nypsi.org
Saturday, February 7, 2015, 10 am – 12 pm
Understanding Psychopathology Through Neuroimaging & Computation with Alan Anticevic, PhD, Assistant Professor of Psychiatry and of Psychology; Administrative Director, NIAAA Center for the Translational Neuroscience of Alcoholism
Free and open to the public
RSVP is appreciated but not required; first come, first-seated
To register, click HERE or visit nypsi.org
Neuropsychiatric disorders such as schizophrenia profoundly alter the structure and function of distributed neural networks and presents a massive health and economic burden. Non-invasive functional neuroimaging tools have evolved sufficiently to allow reliable characterization of large-scale distributed neural systems in humans. Such approaches have been applied to better understand large-scale neural network disturbances in neuropsychiatric disease, particularly using task-based and resting-state techniques. However, human neuroimaging does not yet allow the evaluation of individual neurons within local circuits, where pharmacological treatments ultimately exert their effects. This limitation constitutes an important obstacle to the effort to translate findings from animal research to humans and from healthy humans to patient populations. Integrating new neuroscientific tools may help to bridge these gaps. Two complementary approaches are discussed in the context of understanding cognitive deficits in schizophrenia – namely computational modeling and pharmacological neuroimaging. First, we discuss behavioral and neuroimaging studies that combine causal pharmacological manipulations in healthy volunteers and neurobiologically-grounded computational models. Specific focus is placed on neuroimaging studies using the NMDA receptor antagonist, ketamine, to probe glutamate synaptic dysfunction associated with schizophrenia. Second, we discuss the extension of the models to help understand pharmacological task-based findings in the context of working memory. Finally, clinical resting-state neuroimaging findings across schizophrenia illness stages are discussed in relation to pharmacological effects and computational models extended to the level of large-scale networks. In summary, the argument is presented that linking experimental neuroimaging studies in humans with causal pharmacological manipulations that can be incorporated into computational models may advance the effort to bridge levels of analysis in clinical neuroscience.
Educational Objectives:
After attending, participants will be able to:
Describe how neuroimaging has advanced our understanding of neural disruptions in psychiatric disorders
2. Illustrate how harnessing neuroscience principles through computation can inform mechanisms in psychiatric disorders
Physicians:
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of the American Psychoanalytic Association and the New York Psychoanalytic Society and Institute. The American Psychoanalytic Association is accredited by the ACCME to provide continuing medical education for physicians.
The American Psychoanalytic Association designates this Live Activity for a maximum of [2] AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
IMPORTANT DISCLOSURE INFORMATION FOR ALL LEARNERS: None of the planners and presenters of this CME program have any relevant financial relationships to disclose.
Psychologists:
New York Psychoanalytic Society & Institute is approved by the American Psychological Association (APA) to sponsor continuing education programs for psychologists. NYPSI maintains responsibility for this program and its content. APA-approved CE credits are granted to participants with documented attendance and completed evaluation forms.
DISCLOSURE: None of the planners and presenters of this CE program have any relevant financial relationships to disclose.
Persons with disabilities: The building is wheelchair accessible and has an elevator. Please notify the registrar in advance if you require accommodations.
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